Postdoctoral Fellow in Cellular and Molecular Immunology, Full Time Position
This NIH funded laboratory investigates the molecular and cellular determinants of alloantigen specific tolerance using murine models of cardiac and pancreatic islet transplantation. Specific investigations involve the determination of mechanisms responsible for remodeling of secondary lymphoid organ structure, and how those mechanisms drive T cell migration, differentiation, and fate determination. The molecular focus of the investigations is directed to chemokines, chemokine receptors, cytokines, sphingosine receptors, lymphotoxin, and stromal fibers. Specific cellular elements include regulatory suppressive T cells, effector T cells, vascular and lymphatic endothelial cells, stromal cells, and dendritic cell subsets. Techniques include heavy reliance on in vivo animal models, migration and trafficking assays, real time imaging and advanced microscopy, multicolor flow and sorting, and a variety of molecular techniques for proteins and nucleic acids.
Successful candidates will have at a minimum a recent PhD in immunology or a highly related biomedical field, demonstration of success in publication and presentation, and familiarity or expertise in many of the techniques utilized by the lab.
Piao W, Xiong Y, Famulski K, Brinkman CC, Li L, Wagner C, Saxena V, Simon T, Bromberg JS. Regulation of T cell afferent lymphatic migration by targeting LTbetaR-mediated non-classical NFkappaB signaling. Nature Comm. 2018, 9:3020. doi: 10.1038/s41467-018-05412-0
Bromberg JS, Hittle L, Xiong Y, Saxena V, Smyth EM, Li L, Zhang T, Wagner C, Fricke WF, Simon T, Brinkman CC, Mongodin EF. Gut microbiota-dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes. J Clin Invest Insight 2018, doi: 10.1172/jci.insight.121045
Xiong Y, Piao W, Brinkman CC, Li L, Kulinski JM, Olivera A, Cartier A, Hla T, Hippen K, Blazar B, Schwab SR, Bromberg JS. Sphingosine 1-phosphate (S1P) receptors differentially regulate CD4 T cell migration across afferent lymphatic endothelium. Science Immunology 2019, 4:eaav1263. doi: 10.1126/sciimmunol.aav1263
Please send letter of interest, your contact information, CV, and list of three references to:
Jonathan S. Bromberg, MD, PhD
Vice Chair for Research
Professor of Surgery and Microbiology and Immunology
Center for Vascular and Inflammatory Diseases
University of Maryland
22 S. Greene St., S8B06
Baltimore, MD 21201