NUFFIELD DEPARTMENT OF ORTHOPAEDICS, RHEUMATOLOGY AND MUSCULOSKELETAL SCIENCES (NDORMS)
Postdoctoral Research Associate in Structural Biology/Biochemistry (144973)
Grade 7: Salary £32,817 – £40,322 per annum
There is an exciting opportunity for a Postdoctoral Research Associate in Structural Biology/Biochemistry in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) based at the Botnar Research Centre, Oxford. The laboratory of Dr John Christianson is seeking an exceptional, enthusiastic and motivated scientist to work on a research project investigating protein degradation mechanisms in cancer. You will join an interdisciplinary team of experimental scientists working in the fields of cell biology and myeloma drug resistance as part of the newly formed Oxford Centre for Translational Myeloma Research.
In this role, you will be developing methodology to biochemically and structurally characterise ubiquitin ligase complexes (e.g. design of expression constructs, design of large-scale purification protocols, crystallisation trials, sample optimisation, functional assays, etc). You will design and perform research work using in vitro systems and screening platforms. You will manage your own academic research and administrative activities, while contributing to the dissemination of research group findings by authorship of manuscripts, presentations at meetings, and the group’s website.
We are seeking an individual with a PhD/DPhil (or be near completion) in Biochemistry, Structural Biology, Cell/Molecular Biology, or related discipline. You will have previous laboratory experience, good communication skills, and an ability to work both independently and as part of a team. An experience in structural biology and/or biochemistry of membrane proteins or the ubiquitin-proteasome system biology as well as experience in standard and advanced Cell/Molecular Biology and Biochemistry techniques are essential. Experience in assay development and small molecule screening, Alpha-screens and/or in vitro reconstitution is desirable.
This is a full-time fixed term appointment for 3 years.
The closing date for this position is 12 noon on Monday 2nd March 2020. You will be required to upload a CV and supporting statement as part of your online application.
To apply for this role and for further details, including the job description and selection criteria, please click on the link below: