We look for a highly motivated postdoctoral fellow. This position will be supported by an NIH R01 grant that starts in July 2022. We study vascular and lymphatic biology, cancer biology, immunology, and regenerative medicine by employing 3D tissue engineering, organs-on-chip, organoids in vitro platforms, molecular biology methods, and in vivo animal models. We encourage open-minded persons from different backgrounds to apply for the position. The potential start date would be July 1, 2022, but it can be adjusted depending on the candidate's preference and the visa process.
Below is the expertise we seek, but it can be flexible based on the candidate's background and interest.
To deepen our understanding of adaptive immunity and lymph node/lymphoid organ biology
Purification, adaptation, activation, and FACS characterization of immune cells (dendritic cells, T/B lymphocytes) obtained from animal and human samples.
Monitoring immunity in vitro and in vivo.
Modeling systemic/local infections in animal models and in vitro models.
In vivo imaging (live or fixed samples) of immune cells and lymphoid organs in mice.
Expertise in cancer immunology, lymph nodes, and lymphoid organs is a plus.
To deepen the understanding of blood and lymphatic vascular morphogenesis, homeostasis, and pathogenesis.
Purification, maintaining, and culturing of human blood/lymphatic vascular endothelial cells and vascular mural cells (pericytes, smooth muscle cells, etc.) using animal and human samples.
Monitoring vascular morphology and function in vitro and in vivo.
Monitoring tumor/immune cell interactions to vasculatures in vitro and in vivo.
Expertise in vivo implantation of engineered tissues is a plus.
Expertise in vascular disease animal models in vivo (lymphedema, hypertension, vascular leakage, etc.) is a plus.
To deepen our understanding of tumor initiation, progression, and interactions with blood and lymphatic vascular structures
Knowledge of the mechanobiology of epithelial tumor cells is a plus
Monitoring tumor interactions to vasculature in vitro and in vivo.
Experience in developing tissue-level 3D mono/multi-cellular structure in vitro is a plus.
Experience in organoids, stem cells, multicellular behaviors, and cells in shear stress is a plus.
To apply the organoid technologies to host immunity, vascular, lymphatic, cancer, and organ regenerative medicine
iPSCs differentiation to specific cell types (e.g., liver, gut, brain, heart, endothelial cells, pericytes, etc.).
Monitoring and characterizing organoid development in vitro and in vivo.
To deepen our mechanistic understanding of our findings.
Knowledge and experience in cloning and genetic engineering in mammalian cells to generate knock-out or knock-in cells (e.g., CRISPR-cas9), and to visualize (e.g., GFP, RFP) specific proteins in the cells for live observation of the proteins.
Experience in vascular, immune, and cancer biology is a plus.
How to apply: Send your cover letter and current CV that includes your degree information, publications, and the list of 3 references to Dr. Lee.
Please reference AcademicKeys.com in your cover letter when
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