Immunology & Infectious Diseases Biomedical Sciences Health Sciences - General
A full-time Postdoctoral position is immediately available from the laboratory of Dr. Jonathan Bromberg in the Center for Vascular and Inflammatory Diseases and Surgery department, at University of Maryland School of Medicine. The recently funded research project focuses on signaling pathways that control immune cell migration and cancer cell migration/metastasis, and their roles in cancer biology and therapy. The Dr. Jonathan Bromberg lab (https://www.medschool.umaryland.edu/surgery/Research-/Research-Divisions/Transplant-Surgery-Research/Jonathan-Bromberg-MD-PhD/) utilizes cellular, genetic approaches and next-generation sequencing methods to discover key determinants of immune cell migration and function. The molecular focus of the project is directed to NFkB signal pathway regulated genes related to tumor progression and migration/metastases. Specific cellular elements include regulatory suppressive T cells, effector T cells, vascular and lymphatic endothelial cells, stromal cells, and dendritic cell subsets. Techniques include heavy reliance on in vivo animal models, migration and trafficking assays.
Successful candidates with recent PhD in biology or life sciences will have lab research training in cell and molecular biology. Experience with mice tumor model (e.g., melanoma, breast cancer) is a plus, but not required.
Expectations: Funding is available for three years. Motivated self-starter with the ability to participate creatively in collaborative teams across the laboratory is most welcome.
Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, Lape IT, Paluskievicz C, Hippen KL, Lee Y, Silverman E, Shirkey MW, Riella LV, Blazar BR, Bromberg JS. PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Nature Comm. 2022 Apr 21;13(1):2176. DOI: 10.1038/s41467-022-29930-0.
Xiong Y, Piao W, Brinkman CC, Li L, Kulinski JM, Olivera A, Cartier A, Hla T, Hippen K, Blazar B, Schwab SR, Bromberg JS. Sphingosine 1-phosphate (S1P) receptors differentially regulate CD4 T cell migration across afferent lymphatic endothelium. Science Immunology 2019,4(33): eaav1263. DOI: 10.1126/sciimmunol.aav1263
Piao W, Xiong Y, Li L, Saxena V, Smith KD, Hippen KL, Paluskievicz C, Willsonshirkey M, Blazar BR, Abdi R, Bromberg JS. Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration. Cell Rep. 2020 Jan 28;30(4):1052-1062.e5. DOI: 10.1016/j.celrep.2019.12.083.
Piao W, Xiong Y, Famulski K, Brinkman CC, Li L, Wagner C, Saxena V, Simon T, Bromberg JS. Regulation of T cell afferent lymphatic migration by targeting LTbR-mediated non-classical NFB signaling. Nature Comm. 2018, 9:3020. DOI: 10.1038/s41467-018-05412-0
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