The laboratory of Alex Carll, Ph.D., M.S.P.H. is seeking enthusiastic and motivated postdoctoral research candidates. Our lab investigates how environmental stressors affect cardiac function, and identifies factors that alter stressor susceptibility, to guide risk estimates, regulations, and interventions. Using both rodent and human studies, we explore the mechanisms by which inhaled toxins induce cardiac electrical and mechanical dysfunction, including autonomic nervous system imbalance.
Our recently funded NIH/FDA grants focus on testing the role of different e-cigarette device types and settings, as well as individual constituents of e-cig aerosols, in cardiac dysfunction and autonomic imbalance in mice. Studies involve analyses of electrocardiograms, cardiac electrograms, and echocardiograms, involving conventional approaches and artificial intelligence. Other goals within our lab include determining the intracellular signaling pathways by which inhaled toxins induce cardiac dysfunction in animals, and complementing our animal studies with clinical and/or epidemiologic investigations. Beyond electronic cigarette aerosols, we also investigate the mechanisms of adverse cardiac effects of inhaled volatile organic compounds (VOCs), particulate matter, and tobacco smoke.
Academic Setting: The Carll lab interfaces with an exceptionally collaborative team of investigators focused on environmental cardiology within the newly formed Christina Lee Brown Envirome Institute at the University of Louisville. Dr. Carll is an investigator within the American Heart Association (AHA) Tobacco Regulation and Addiction Center and also an investigator in the Diabetes and Obesity Center. He is an Assistant Professor in the Department of Physiology in the School of Medicine at the University of Louisville.
Successful candidates will have a background in physiology, toxicology, public health, environmental health, or a closely related field, and experience with animal models. A solid track-record of publishing, and strong internal motivation are essential. Experience in physiology, large datasets, animal research (injection, surgical implants, organ processing), and statistics are preferred but not required. Familiarity with molecular laboratory techniques (Western, ELISA, and/or qRTPCR) or convolutional neural networks is valued. The individual will be expected to design and perform studies, present at national meetings, and compose original research articles.
Interested candidates should submit a cover letter, CV, and three references via e-mail.