The primary focus of Dr. McDonald´s research program is on mechanisms of cellular aging and the interaction between nutrition and aging. Current topics of investigation include:
Evaluation of the rates of aging from gradual aging to rapid senescence
Cellular proliferation of brown adipose tissue isolated from aging rodents
Alterations in circadian rhythms of food intake and body temperature during senescence
The interaction among dietary restriction, dietary carbohydrates and lifespan
Hypothalamic dysregulation and alterations in the control of food intake during aging
Dr. McDonald's research uses primarily rodents as models for human aging. Research methods include cell culture, in vitro and in vivo analysis of cell proliferation, food intake analysis, analysis of circadian rhythm and extensive use of computers for data collection, systems modeling and statistical analysis.