Dr. Gretebeck’s program of research focuses on the study of energy and macronutrient metabolism. His background in both nutrition and exercise physiology has resulted in a research trajectory that encompasses the measurement of metabolic responses to manipulations in both diet and exercise. He has expertise in the assessment of energy intake and expenditure and is currently developing a novel approach using heart rate variability to assess metabolic flexibility as a screening tool for insulin resistance. Dr. Gretebeck has recently completed a diet and exercise study investigating the role of exercise and a low carbohydrate diet on insulin resistance and prediabetes in individuals at risk for the development of Alzheimer’s disease.