Examine how epigenetically silenced tumor suppressor genes influence tumor initiation, progression and metastasis in breast and pancreatic cancers. My long-term research objective is to examine how aberrant signaling molecules regulate epigenomes and lead to a wide spectrum of malignant phenotypes , primarily in breast and pancreatic cancers. The ultimate goals are: to identify the microenvironmental cause (s) leading to tumorigenesis, decipher how dysregulated signaling pathways contribute to neoplasm by altering epigenomes, discover potential diagnostic bio-markers, and develop specific therapeutic strategies by correcting signaling molecules.
