Dr. Chen’s research interests focus on statistical genomics for cancer research, especially developing and applying innovative statistical and bioinformatics methodology to facilitate translational genomic research from bench to clinic. Dr. Chen is the Principle Investigator of a NCI R01 grant “Integrative prediction models for metastasis risk in colon cancer” which collects data on mRNA expression, somatic mutations, and clinical information to develop clinical-genomic risk prediction models and to identify subtypes for colon cancer patients. Dr. Chen is also a major contributor for identifying six triple-negative breast cancer (TNBC) subtypes and corresponding gene signatures. He is the developer of the web-based software “TNBCtype”, which has been widely used by the breast cancer research community.
